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Learning Center / General / Lisinopril Drug Overview: Uses, Costs, Insurance Coverage and Considerations

Lisinopril Drug Overview: Uses, Costs, Insurance Coverage and Considerations

December 14, 2023

Lisinopril Drug Overview: Uses, Costs, Insurance Coverage and Considerations

What is lisinopril?


Lisinopril is a medication classified as an angiotensin-converting enzyme (ACE) inhibitor. Widely recognized for its efficacy, lisinopril may play a pivotal role in helping you enhance your cardiovascular health. 


In this overview, we aim to uncover the fundamental aspects and information related to lisinopril and its potential positive effects on your cardiovascular health.


What is lisinopril used for?


Lisinopril is a medication primarily used to treat high blood pressure (hypertension). It belongs to a class of drugs known as angiotensin-converting enzyme (ACE) inhibitors. By blocking the action of ACE, lisinopril helps relax your blood vessels, allowing blood to flow more smoothly. This effect helps reduce your blood pressure, lowering the risk of complications such as strokes, heart attacks, and kidney problems.


In addition to hypertension, lisinopril is used in the management of heart failure and as part of the treatment plan following a heart attack. The medication is sometimes prescribed in combination with other drugs to help you achieve optimal blood pressure control.


Lisinopril Dosing Instructions


The appropriate dosage of lisinopril is determined by several factors, including the strength of the medication. Additionally, the frequency of doses, the intervals between doses, and the duration of treatment are dependent on the medical condition being addressed. Here are general dosing instructions for oral dosage forms (solution or tablets):


  • For high blood pressure:
    • Adults—At first, 10 milligrams (mg) once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 40 mg per day.
    • Children 6 years of age and older—Dose is based on body weight and must be determined by your doctor. The starting dose is usually 0.07 mg per kilogram (kg) of body weight per day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 0.61 mg per kg of body weight or 40 mg per day.
    • Children younger than 6 years of age—Use is not recommended.
  • For heart failure:
    • Adults—At first, 5 milligrams (mg) once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 40 mg per day.
    • Children—Use and dose must be determined by your doctor.
  • For immediate treatment after a heart attack:
    • Adults—At first, 5 milligrams (mg), followed by 5 mg after 24 hours, followed by 10 mg after 48 hours, and then 10 mg once a day.
    • Children—Use and dose must be determined by your doctor.


It's essential to follow the healthcare provider's recommendations and undergo regular check-ups to monitor your blood pressure and assess the effectiveness of the medication. Dosage adjustments may be made as needed.


Lisinopril Administration Instructions


Here are general guidelines for the administration of lisinopril:


  • Lisinopril comes as a tablet and a solution (liquid) to take by mouth and is usually taken once a day. 
  • To help you remember to take lisinopril, take it around the same time every day. 
  • You may take lisinopril with or without food.
  • Take lisinopril exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
  • If you are taking the solution, measure the liquid medicine with the supplied measuring device (not a kitchen spoon).


Follow prescribed lisinopril guidelines precisely. Adhere to label instructions, seek clarification when needed, and take it as directed by your healthcare professional. Avoid adjusting dosage without medical guidance and refrain from overuse. Strict adherence ensures safe and effective use for your medical condition.


How much does lisinopril cost?


The cost of lisinopril can vary depending on factors such as the dosage, quantity, and where you purchase it. On average, the cost for a 30-day supply of generic lisinopril ranges from $3 to $60, depending on the source and whether you have insurance coverage.


Several resources can provide you with discounts and savings tips. For instance, lisinopril pricing can be as low as $3 per month, and discount coupons are available, making it potentially more affordable. Additionally, programs like GoodRx and SingleCare, and discount coupons from various pharmacies, can further reduce the out-of-pocket expenses for the medication.


It's advisable to compare prices at different pharmacies, use available discounts, and check with your insurance provider to determine the most cost-effective option for obtaining lisinopril.


How does lisinopril work?


Lisinopril functions by inhibiting the renin–angiotensin–aldosterone system. Specifically, it prevents the conversion of angiotensin I to angiotensin II, a substance that narrows blood vessels. By inhibiting this conversion, lisinopril reduces the levels of angiotensin II, leading to vasodilation and a decrease in blood pressure.


ACE inhibitors, including lisinopril, play a crucial role in managing conditions such as high blood pressure and heart failure. Additionally, lisinopril may have protective effects on your heart and kidneys, making it a valuable medication in various cardiovascular conditions.


Understanding the mechanism of action of lisinopril may help you in appreciating its role in regulating blood pressure and its broader therapeutic applications in cardiovascular health.


Is lisinopril covered by insurance?


Yes, lisinopril is commonly covered by insurance plans, with 100% coverage reported for Medicare Advantage plans and Medicare Part D plans in 2023, according to GoodRx. It's crucial to note that coverage details can vary among different insurance providers. To obtain accurate and up-to-date information, it's recommended to contact your specific insurance provider and inquire about the coverage for lisinopril.


Moreover, some insurance plans implement tiered drug coverage systems, where drugs are categorized into different tiers with varying copayments. To ensure you understand the cost implications, it's essential to be aware of your insurance plan's specific coverage for lisinopril. This information can typically be found in your plan's formulary, a list of covered drugs, along with their respective tiers and associated costs.


Checking the formulary and consulting with your insurance provider will empower you to make informed decisions about your medication costs and coverage, ensuring you receive the necessary prescription drugs at the most affordable rates.


What to consider before taking lisinopril


Before you take lisinopril, consider the following:


  • Contraindications: If you have a history of angioedema related to previous treatment with an angiotensin-converting enzyme (ACE) inhibitor or if you have hereditary or idiopathic angioedema, lisinopril is contraindicated for you.
  • Blood Pressure Monitoring: Regularly monitor your blood pressure, as lisinopril aims to lower blood pressure and reduce the risk of strokes and heart attacks.
  • Lifestyle Recommendations: It’s recommended to follow a healthy lifestyle, including regular exercise and a healthy diet, to enhance the effectiveness of lisinopril.
  • Potential Side Effects: Be aware of possible side effects such as dizziness or fainting, and promptly notify the physician if signs of these occur.


The information provided in this article is for general informational purposes only. It is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or another qualified healthcare provider with any questions you may have regarding a medical condition or procedure. The content within this article is based on publicly available sources and expert knowledge at the time of publication. While we strive to provide accurate and up-to-date information, no guarantee is made regarding the accuracy, completeness, or timeliness of the content. Medical knowledge is constantly evolving, and new research may impact the understanding of various medical conditions and procedures. This article may include links to external websites or resources for additional information. We do not endorse or control the content of these external sites and are not responsible for the accuracy or reliability of the information they contain. By reading this article, you agree that you understand and accept the terms of this disclaimer. If you do not agree with these terms, please refrain from visiting this page. Any reliance you place on the information provided in this article is strictly at your own risk. We disclaim all liability for any actions taken or not taken based on the information in this article. If you believe you have a medical emergency, please immediately seek medical attention, or call your local emergency number.




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