Generic name

Buprenorphine HCl/Naloxone HCl

Covered by Medicare


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Average Annual Cost per Beneficiary


Average cost per year*

Average Annual Cost per Dose



Average cost per beneficiary*


  • Sun Pharmaceuti
  • Sandoz
  • Rhodes Pharmace
  • Mylan
  • Mallinckrodt Ph
  • Major Pharmaceu
  • Lannett Co. Inc
  • West-Ward/Hikma
  • Hi-Tech/Akorn C
  • Dr.Reddy'S Lab
  • Amneal Pharmace
  • Alvogen Inc
  • Almatica Pharma
  • Actavis/Teva
  • Accord Healthca

What is Buprenorphine-Naloxone

This medication contains 2 medicines: buprenorphine and naloxone. It is used to treat opioid dependence/addiction. Buprenorphine belongs to a class of drugs called mixed opioid agonist-antagonists. Buprenorphine helps prevent withdrawal symptoms caused by stopping other opioids. Naloxone is an opioid antagonist that blocks the effect of opioids and can cause severe opioid withdrawal when injected. Withdrawal is less likely when naloxone is taken by mouth, dissolved under the tongue, or dissolved on the inside of the cheek. It is combined with buprenorphine to prevent abuse and misuse (injection) of this medication. This combination medication is used as part of a complete treatment program for drug abuse (such as compliance monitoring, counseling, behavioral contract, lifestyle changes). NOTE: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

Drug Trends

*Origin of the terms and chart data used within this page: https://data.cms.gov/

Common Questions About Buprenorphine-Naloxone

Yes, Buprenorphine-Naloxone is covered by Medicare.

In 2021, the average cost per dose of Buprenorphine-Naloxone was $4.01.

The average dose of Buprenorphine-Naloxone received per year is 30,313,191 units

123,782 Medicare beneficiaries received Buprenorphine-Naloxone in 2021, which was a 0.13% from 2020

There were 1,307,393 claims made by Medicare beneficiaries, which is a 0.13% from 2020

The average spending amount per claim in 2021 was $165.12

The average Medicare spending per beneficiary amount for Buprenorphine-Naloxone was $1,743.99

The most expensive manufacturer of Buprenorphine-Naloxone is Sandoz

Major Pharmaceu is the least expensive manufacturer with an Average Spending Per Dosage Unit of $1.60

Alvogen Inc received $96,841,537.42

The total amount spent on Buprenorphine-Naloxone by Medicare is $215,874,680.78

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